Fort Lauderdale-Hollywood Airport will be closed Saturday and Sunday, with the last flight departing at 7.45pm (19:45) Friday.
In an alert on its website, American Airlines wrote, "Hurricane Irma is projected to make landfall in South Florida this weekend". Unlike American, Delta, and JetBlue, United does not have a hub in Florida or Georgia.
American accounts for 38% of the flying in the Miami-Ft.
All major USA carriers were waiving change fees to the region.
But the prospect of a direct hit from Irma represents another blow to USA air travel in one of the busiest air corridors in the world for business and leisure travel.
Meanwhile, Alejandra Carriazo from Miami had a flight to Ithaca, New York but it was cancelled. SAVE, +2.41% at 102 and American Airlines Group Inc.
The decision to close Orlando International was made Friday, after meetings with the airport's airline carriers.
JetBlue Airways said on Wednesday afternoon that it had cancelled about 130 flights. Southwest Airlines is the largest single operator in Orlando at 20%. The company put the total at 6,896 as of 6 p.m. ET. It is also shutting operations in Fort Lauderdale, Fort Myers and West Palm Beach.
The cheapest flight on Delta on the same route on Friday was $550.
Amid accusations of price gouging, various airways announced that they were capping ticket costs, relaxing scheduling procedures or waiving additional fees as people scrambled to leave the region.
Irma, a Category 5 storm and one of the most powerful Atlantic hurricanes recorded in history, has torn through several Caribbean islands and is heading toward South Florida.
Delta said Orlando's passenger tram system may close due to high winds expected Sunday night.
A motorist arrives to the find plastic bags covering the handles of empty gasoline pumps in Parrish, Florida, as residents evacuate parts of the state ahead of Hurricane Irma.
Airport officials urge travelers to check the status of their flight before coming to OIA.
Florida State and Florida canceled their Saturday home football games Thursday because of Hu...
According to the FAA, air traffic controllers will remain on duty and will have to take shelter in nearby buildings and lower levels of the control tower. The airport tweeted that it will "cease commercial airline operations" at 8 p.m. Saturday.
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